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Free radicals, owing to their instability and consequent erratic behavior, have the potential to cause cell damage that would be virtually unlimited without antioxidants to hold their numbers in check and glutathione, which is the only antioxidant that is known to occur naturally within the cells is the master antioxidant. Although it was first identified in 1888, it was not until almost a century later that scientists began to undertake through investigations into the role that it plays in human metabolism

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Graphical Abstract Similar content being viewed by others Introduction The pharmacokinetics of drugs represent a major pre-step to reflect drug response and the subsequent adverse drug reactions (ADRs)

22 Prevalence and Geographic Distribution Deficiency of G6PD is the most common metabolic disorder of red blood cells and has been estimated to affect over 400 million people worldwide

Matson et al., 2011)

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